Dilated cardiomyopathy (DCM) is one of the common diseases leading to heart failure, arrhythmia and sudden death. The etiology of DCM is complex and diverse, the mechanism has not been fully elucidated, and the intervention has limited improvement in the prognosis of patients, with a 10-year survival rate of less than 25%. This study aimed to summarize the construction characteristics of DCM animal model and evaluated the clinical compatibility of the model with traditional Chinese and western medicine based on domestic and foreign research results of DCM animal model, Western clinical diagnostic criteria and TCM syndrome differentiation. It was found that DCM modeling methods mainly involved gene editing, drug induction, immune induction, viral infection, rapid pacing induction. Experimental animals mainly included muroid, zebrafish, drosophila, pigs, thereinto, mice and rats were most commonly used. Gene editing was the most commonly used animal model of DCM, followed by doxorubicin-induced model. The literature review showed that experimental animals, drugs, single or cumulative doses, administration methods, and modeling period varied in different studies about the same DCM animal model. The level of clinical anastomosis of traditional Chinese and western medicine varied considerably, and the clinical anastomosis of traditional Chinese medicine was generally lower than that of Western medicine in the same model. In addition, the modeling standards of DCM animal models were mostly based on Western medicine theories, and the differentiation standards of syndrome models and the information collection standards of the four diagnoses have not been standardized and unified. In the future, stable and homogeneous animal models with high clinical consistency combining of disease and syndrome need to be established to provide a basis for DCM mechanism research and new drug development.