【】Systemic lupus erythematosus (SLE) models are mainly divided into four categories: spontaneous, induced, Humanized Mouse Models and gene knockout models. Lupus animal models are of great significance for the study of the etiology, pathogenesis and treatment of SLE. By reviewing and comparing various lupus animal models, this paper elucidates the main features, advantages and disadvantages of different types of SLE models, and provides a reference for researchers to select appropriate models in the process of exploring genetic and environmental factors, new pathogenic mechanisms and therapeutic modalities of systemic lupus erythematosus.