【】 Alzheimer"s disease (AD) is a degenerative disease of the central nervous system, which is mainly manifested by cognitive dysfunction and speech loss, and its pathogenesis is associated to many factors. In recent years, zebrafish has attracted extensive attention due to its high homology with human in brain structure and function, nerve conduction and AD pathogenic genes. In this paper, we reviewed the advantages of zebrafish as an animal model to explore the pathogenesis of AD, AD drug screening, and drug evaluation, to provide new insights for the pathogenesis of AD and new drug development.