非酒精性脂肪性肝病动物模型制备及病证结合研究进展
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1.甘肃中医药大学;2.甘肃省中医院

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]甘肃省科技计划资助-青年科技(23JRRA1728);甘肃省教育厅高校教师创新(2023A-093);甘肃中医药大学科学研究与创新(2022KCYB-10);甘肃省名中医传承工作室(国中医药规财函[2021]242号)。


Research progress on the preparation of animal models of non-alcoholic fatty liver disease and the combination of disease and syndrome
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Affiliation:

1.Gansu University of Traditional Chinese Medicine;2.Gansu Provincial Hospital of Traditional Chinese Medicine

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Funded by Science and Technology Program of Gansu Province - Youth Science and Technology Fund Project(No. 23JRRA1728);Funded by Gansu Provincial Department of Education Innovation Fund for University Teachers(No. 2023A-093);Funded by Scientific Research and Innovation Fund of Gansu University of Traditional Chinese Medicine(No. 2022KCYB-10);Funded by Gansu Province famous Traditional Chinese Medicine Inheritance Studio (Guochaihan [2021] No. 242).

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    摘要:

    非酒精性脂肪性肝病(NAFLD)是指多种致病因素引起的,以脂肪在肝细胞内过度沉积为主要病变特征的代谢综合征。目前,NAFLD的发病机制尚未完全清楚,临床上缺乏针对NAFLD的特效药物。因此,建立理想动物模型在NAFLD发病机制的明确、特效药物研制及治疗方面显得极为重要。近五年来,除NAFLD动物模型被热议外,随着中医药事业的不断更新、发展,与NAFLD相关的病证结合模型也相继增多,现将近五年来常用的NAFLD动物模型及其制备和评价方法作一总结,以期为同道在今后NAFLD动物模型制备及病证结合研究方面提供参考。

    Abstract:

    Non-alcoholic fatty liver disease (NAFLD) is a metabolic syndrome caused by a variety of pathogenic factors and characterized by excessive deposition of fat in liver cells. At present, the pathogenesis of NAFLD is not fully understood, and there is a lack of specific drugs for NAFLD in clinical practice. Therefore, the establishment of an ideal animal model is extremely important for the clarification of the pathogenesis of NAFLD, the development of specific drugs and treatment. In the past five years, in addition to NAFLD animal models, with the continuous renewal and development of traditional Chinese medicine, there have been more and more disease-syndrome combined models related to NAFLD. This article summarizes the NAFLD animal models commonly used in the past five years, their preparation and evaluation methods, in order to provide reference for the future study of NAFLD animal model preparation and the combination of disease and syndrome.

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  • 收稿日期:2024-02-25
  • 最后修改日期:2024-09-13
  • 录用日期:2024-12-02
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