基于数据挖掘的盆腔炎性疾病后遗症动物模型分析
DOI:
CSTR:
作者:
作者单位:

1.山东中医药大学附属医院;2.山东中医药大学

作者简介:

通讯作者:

中图分类号:

基金项目:

山东省自然科学基金(ZR2022QH075,ZR2021MH079),山东省中医药科技发展计划项目(M-2023234T)Fund:Funded by the Shandong Provincial Natural Science Foundation(ZR2022QH075,ZR2021MH079), Shandong Province Traditional Chinese Medicine Science and Technology Development Project(M-2023234T)


Analysis of Animal Models of Sequelae of Pelvic Inflammatory Disease Based on Data Mining
Author:
Affiliation:

1.The Affiliated Hospital of Shandong University of TCM;2.Shandong University of Traditional Chinese Medicine

Fund Project:

Funded by the Shandong Provincial Natural Science Foundation(ZR2022QH075,ZR2021MH079), Shandong Province Traditional Chinese Medicine Science and Technology Development Project(M-2023234T)

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的 梳理盆腔炎性疾病后遗症(SPID)动物模型特点,为规范造模流程、提高成模率提供参考。方法 检索近40年有关SPID动物模型的文献,总结并分析动物种类、造模方法、周期、物质、阳性对照药、评价指标等。结果 纳入243篇文献,多采用苯酚胶浆法或微生物感染法诱导大鼠建立SPID模型,造模周期在14-16天为主,大多以盆腔组织形态观察和病理HE染色判定模型成功与否;中医病症结合模型研究较少。结论 SPID动物模型造模方法缺乏一致性的判定标准,建议综合动物行为学变化、盆腔组织形态学改变以及病理等进行评价;其次,中医证候造模缺乏有效的方法和评价标准,有待进一步研究发展;最后,阳性对照药的选取和使用时限需要进一步探索完善。

    Abstract:

    Objective:The characteristics of animal models of sequelae of pelvic inflammatory disease (SPID) were reviewed to provide a reference for standardizing the modeling process and improving the molding rate.Methods:The literature on animal models of SPID in the past 40 years was searched, and animal species, modeling methods, modeling cycles, modeling substances, positive control drugs, and evaluation indexes were summarized and analyzed.Results:A total of 243 literatures were included, most of which were induced by phenol paste method and microbial infection method to establish SPID model in rats. The modeling cycle was mainly 14-16 days, and the success of the model was mostly determined by pelvic tissue morphology observation and pathological HE staining. There are few researches on TCM disease combination model.Conclusion:The method of SPID animal model modeling lacks consistent criteria, so it is recommended to evaluate the changes of animal behavior, pelvic histomorphology and pathology. Secondly, TCM syndrome modeling lacks effective methods and evaluation standards, which need further research and development; Finally, the selection and use cycle of positive control drugs need to be further explored and perfected.

    参考文献
    相似文献
    引证文献
引用本文
分享
相关视频

文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2024-03-01
  • 最后修改日期:2024-06-11
  • 录用日期:2024-07-04
  • 在线发布日期:
  • 出版日期:
文章二维码
防诈骗提示!请勿点击不明链接或添加个人微信。编辑部所有邮箱后缀均为@cnilas.org
关闭