Type 2 diabetes mellitus is a common metabolic disease characterized by hyperglycaemia and insulin resistance. Peri-implantitis is a common complication of oral implant. Type 2 diabetes mellitus can enhance bone destruction in peri-implantitis. However, the mechanism of association between the two has not been fully elucidated, and it is necessary to establish an effective animal model of type 2 diabetes mellitus complicated with peri-implantitis. At present, several methods have been proposed to construct rodent models of type 2 diabetes mellitus combined with peri-implantitis. This article reviews the establishment of rodent models of type 2 diabetes mellitus complicated with peri-implantitis. It can provide reference for the prevention, treatments and the establishments of animal models of type 2 diabetes patients with peri-implantitis.