Delirium is an acute brain dysfunction syndrome characterized by confusion, confusion, and difficulty concentrating attention, which mainly affects ICU and elderly inpatients. Treatment is not only costly, but also leads to an increased risk of serious complications and death. Due to its complex etiology and unknown pathological mechanism, clinical drug treatment of delirium is largely ineffective. The construction of animal models is a powerful tool to understand the mechanism of delirium, screen new drugs and study intervention measures. This article reviews the experimental research related to delirium animal models at home and abroad in recent years, and summarizes the latest progress in the construction and evaluation methods of delirium animal models from three aspects: animal selection, model construction methods and model evaluation, so as to provide reference for experimental research based on delirium animal mode