Depression is a common chronic mental illness. The animal model of depression is widely used in the study of the pathogenesis of depression and the development of new antidepressant drugs. The consistency and reliability of animal models of depression to simulate human depressive symptoms will directly affect the study results.However,at present, no animal model has been found that is completely consistent with the onset of human depression, which hinders the in-depth study of depression. By using scientific and reasonable modeling and evaluation methods, the pathological state of depression can still be simulated to a large extent,which provides a basis for in-depth understanding of the pathogenesis of depression and further research and development of effective antidepressant drugs. This paper aims to provide reference for researchers by reviewing several commonly used animal models and behavioral tests of depression.