【】Objective The purpose of this paper is to explore the construction method, evaluation system and related indicators of the Qi Yin deficiency syndrome model of type 2 diabetes in Guizhou miniature pigs. Methods Twenty six six month old Guizhou miniature pigs were selected, of which six were fed with basic diet for 10 months in the control group, 20 were fed with high sugar and high fat diet for 10 months in the model group of qi yin deficiency in type 2 diabetes, and three months were fed with Qingpi Fuzi decoction. The model of qi yin deficiency in type 2 diabetes in Guizhou miniature pigs was constructed. Five scales were used to evaluate traditional Chinese medicine syndrome types, including urination, defecation, movement and mental state, response to the surrounding environment, and color of the skin, hair, nose, and disc. Serum CD4+, CD8+, and their ratios, cAMP, cGMP, and their ratios, as well as tongue R, G, and B values were used to evaluate Qi Yin deficiency syndrome. Fasting blood glucose (FPG), glycosylated hemoglobin (HbA1c), glucose tolerance test (OGTT), insulin resistance index (HOMA-IR), TG, TC, HDL-C, LDL-C, PT, APTT and other indicators were used to evaluate and evaluate type 2 diabetes. Results The physical signs of the small pigs in the model group can be summarized as overweight, fatigue and fatigue, tendency to lie down, laziness, lethargy, lack of energy, overeating and drinking, dull fur, and dull fur; The scores for defecation, movement and mental state, response to the surrounding environment, and color of the skin, fur, and nasal disc were relatively low (P<0.05); The tongue appears red with no or little coating; Compared with the normal group, the laboratory indicators of the small pigs in the model group showed FPG HbA1c、HOMA-IR、TC、LDL-C、cAMP、cGMP、 The R, G, and B values of tongue images were significantly reduced, while PT, APTT, CD4, and CD4/CD8 values were significantly reduced. TG was elevated (P>0.05), HDL-C was elevated (P>0.05), and cGMP was elevated (P>0.05); Pathological staining showed destruction of pancreatic tissue. Conclusions The method of using high sugar and high-fat feed combined with traditional Chinese medicine for breaking qi and damaging yin can successfully establish a small pig model of T2DM with qi and yin deficiency. The established model presents the main symptoms of fatigue and fatigue, thirst and thirst, shortness of breath and lazy speech, redness of the tongue and less fluid, lack of moss, and weak pulse in traditional Chinese medicine syndromes, as well as concurrent symptoms such as yellow and transparent urine, dry and dry stools, slow response, curling up, dull and dull fur, gray and dull nasal discs, as well as clinical manifestations of abnormal glucose and lipid metabolism and insulin resistance.