Japanese encephalitis virus (JEV) usually evades the inhibitory effect of innate immunity type I interferon (I-IFN) when infects human cells and tissues, then causes a series of serious symptoms such as spasticity, neurodegenerative lesions, neuroinflammation and even death. Generally, JEV escapes innate immunity by inhibiting IFN-α/βproduction and interferon’ Janus kinase (Jak)-signal transducer and activator of transcription (STAT) signaling pathway. Because of this special immune escape mechanism, various mouse infection models have been constructed for the study of the pathogenesis and therapeutic regimen of JEV infection. In this review, based on the exposition the IFN immune escape mechanism of JEV, we systematically introduced the JEV infected mouse models, analyzed the characteristics of these models and the degree of simulation of human symptoms, etc. To sum up, we hope to develop various new JEV infected mouse models based on the new research targets may be found and provide novel ideal animal models for JEV research.