As a growing public health challenge, senile osteoporosis has a significant impact on the daily life of the elderly population due to its concealment, high prevalence and high risk of disability. Building an animal model that simulates senile osteoporosis is crucial to understanding its pathological mechanism, and will significantly facilitate the development of anti-osteoporosis drugs and the identification of new therapeutic targets. This review reviews the widely used methods of building senile osteoporosis animal models, analyzes their advantages and limitations, and discusses the research progress of animal models in terms of evaluation indicators, so as to provide references for the research of senile osteoporosis animal models.