特发性肺纤维化动物模型的研究进展
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1.成都中医药大学药学院;2.成都中医药大学基础医学院;3.海南医科大学中医学院;4.成都中医药大学附属医院

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成都中医药大学附属医院院基金(2017-D-YY-15)


Research Progress in Animal Models of Idiopathic pulmonary fibrosis
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1.College of Pharmacy, Chengdu University of Traditional Chinese Medicine;2.Chengdu University of Traditional Chinese Medicine School of Basic Medicine;3.College of Traditional Chinese Medicine, Hainan Medical University;4.Hospital of Chengdu University of Traditional Chinese Medicine

Fund Project:

Hospital Fund of Chengdu University of Traditional Chinese Medicine

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    摘要:

    作为一种预后不良的慢性进行性肺病,特发性肺纤维化(idiopathic pulmonary fibrosis, IPF)的发病机制至今尚未明确,其治疗方法仍在不断探索。动物模型的建立对疾病的发病机制与治疗研究具有重要作用。本文将基于IPF动物模型与人IPF在疾病表型等方面的相似度,从药物和环境因素所诱导的纤维化机制、组织病理学改变、纤维化阶段、造模时间等方面梳理IPF动物模型的研究进展,阐述不同动物模型的优缺点及特征。

    Abstract:

    As a chronic progressive lung disease with poor prognosis, the pathogenesis of idiopathic pulmonary fibrosis (IPF) has not yet been clarified, and its treatment is still being explored. The establishment of animal models plays an important role in the study of the pathogenesis and treatment of the disease. Based on the similarity between IPF and human IPF in terms of disease phenotype, this paper will review the research progress of IPF animal models in terms of the fibrosis mechanism induced by drugs and environmental factors, histopathological alterations, fibrosis stage, modelling time, etc., and describe the advantages, disadvantages and characteristics of different animal models.

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  • 收稿日期:2024-09-29
  • 最后修改日期:2025-02-18
  • 录用日期:2025-04-27
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