Abstract:Cancer-induced bone pain (CIBP) not only imposes substantial suffering on cancer patients but also significantly diminishes their quality of life and self-esteem. The mechanisms underlying CIBP are complex and progressively evolve with cancer advancement. Current treatment options show limited efficacy and are often accompanied by adverse effects. Traditional Chinese medicine demonstrates potential advantages in managing CIBP. However, the related analgesic mechanisms remain inadequately understood and require further investigation. Developing a standardized, stable and reproducible animal model is crucial to advancing research on disease pathogenesis and verifying the effectiveness of therapeutic interventions. This review compiles recent methods for modeling CIBP in animals over the past three years and summarizes the application of these models in related analgesic mechanisms of traditional Chinese medicine studies, aiming to guide future research directions in CIBP.