骨癌痛动物模型及中医药作用机制研究进展
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1.重庆大学附属肿瘤医院;2.成都中医药大学针灸推拿学院

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基金项目:

重庆市科卫联合中医药科研项目资助项目(No. 2024ZYDB002)、重庆市自然科学基金面上项目(cstc2021jcyj-msxmX0501)


Research progress on animal model of cancer-induced bone pain and mechanism of action of traditional Chinese medicine
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Affiliation:

1.Chongqing University Cancer Hospital;2.College of Acupuncture and Massage, Chengdu University of Traditional Chinese Medicine

Fund Project:

Chongqing Science and Technology Bureau joint Health Commission of Chinese Medicine research project funded project(No. 2024ZYDB002), Chongqing Natural Science Foundation General Project(No. cstc2021jcyj-msxmX0501)

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    摘要:

    骨癌痛(cancer-induced bone pain,CIBP)不仅给癌症患者带来巨大痛苦,也降低其生活质量和自信心。导致CIBP的机制是复杂的,并随着癌症的进展而发生演变。目前治疗手段效果有限且存在不良反应。中医药在治疗CIBP方面具有一定优势,但相关镇痛机制有待深入探讨。建立典型、稳定、易重复的动物模型是进一步研究疾病发病机制和验证干预措施有效性的前提和基础。本文总结近3年常用的CIBP动物模型造模方法,并总结CIBP动物模型在中医药相关镇痛机制研究的应用,以期为今后的CIBP研究提供方向。

    Abstract:

    Cancer-induced bone pain (CIBP) not only imposes substantial suffering on cancer patients but also significantly diminishes their quality of life and self-esteem. The mechanisms underlying CIBP are complex and progressively evolve with cancer advancement. Current treatment options show limited efficacy and are often accompanied by adverse effects. Traditional Chinese medicine demonstrates potential advantages in managing CIBP. However, the related analgesic mechanisms remain inadequately understood and require further investigation. Developing a standardized, stable and reproducible animal model is crucial to advancing research on disease pathogenesis and verifying the effectiveness of therapeutic interventions. This review compiles recent methods for modeling CIBP in animals over the past three years and summarizes the application of these models in related analgesic mechanisms of traditional Chinese medicine studies, aiming to guide future research directions in CIBP.

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  • 收稿日期:2024-10-16
  • 最后修改日期:2025-05-17
  • 录用日期:2025-05-28
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