特发性肺纤维化动物模型及中药干预作用的研究进展
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1.辽宁中医药大学;2.辽宁中医药大学附属医院

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基金项目:

国家自然科学基金面上项目(82274440); 辽宁省教育厅高校基本科研项目储备项目(2024-JYTCB-040)。


Research Progress in the Animal Model of Idiopathic Pulmonary Fibrosis and the Intervention Effect of Traditional Chinese Medicine
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Affiliation:

1.Liaoning University of Traditional Chinese Medicine;2.The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine

Fund Project:

General Project of National Natural Science Foundation of China (82274440); Liaoning Provincial Department of Education University Basic Scientific Research Project Reserve Project(2024-JYTCB-040)

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    摘要:

    特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)是一种慢性进行性疾病,确诊后生存期较短,目前西药治疗效果欠佳,且肺移植治疗价格高昂,因此亟须寻求新的、安全有效的治疗手段。动物实验研究是验证药物作用机制的重要手段,合理的IPF动物模型建立方法对IPF实验研究尤为重要。当前使用博来霉素(bleomycin,BLM)诱导IPF模型较为普遍。传统中药具有治疗靶点多、不良反应小等优点,在IPF的治疗中正逐渐受到重视。通过中药干预IPF动物模型进而验证中药治疗IPF的具体作用靶点及作用机制是目前实验研究的中心内容。文章通过对IPF动物模型的选用、诱导方法、建立过程、评估方法及中药对模型的干预作用进行综述,总结出IPF动物模型最佳建模方法及中药治疗现状,以期为IPF的科学研究和临床治疗提供依据。

    Abstract:

    Idiopathic pulmonary fibrosis(IPF) is a chronic progressive disease with a short survival time after diagnosis, the current treatment effect of Western medicine is not good, and the price of lung transplantation is high, so there is an urgent need to find new, safe and effective treatments. Animal experiments are an important means to verify the mechanism of action of drugs, and reasonable animal models of IPF are particularly important for IPF experimental research. At present, BLM is commonly used to induce IPF models. Traditional Chinese medicine has the advantages of multiple therapeutic targets and few adverse reactions, and is gradually gaining attention in the treatment of IPF. It is the central content of the current experimental research to verify the specific targets and mechanisms of TCM in the treatment of IPF by intervening in animal models of IPF with traditional Chinese medicine. In this paper, the selection of animal models of IPF, the induction methods and establishment process of the models, the evaluation methods of the models and the intervention effects of traditional Chinese medicine on the models were reviewed, and the best modeling methods of animal models of IPF and the current status of traditional Chinese medicine treatment were summarized, in order to provide a basis for the scientific research and clinical treatment of IPF.

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  • 收稿日期:2024-11-28
  • 最后修改日期:2025-04-01
  • 录用日期:2025-04-30
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