Anxiety, as a major emotional disorder, is manifested in the individual"s expectation of future threats. The incidence rate is about 7.3%, and the lifetime prevalence rate ranks first. There is an overlapping mechanism with depression. Anxiety is a typical symptom of a variety of mental diseases or emotional disorders in traditional Chinese medicine. The high rate of comorbidity and disability seriously endangers people"s health. Animal models, as important carriers for studying anxiety, are of great significance in deciphering the pathogenesis of anxiety and developing drugs. However, the traditional paradigm of stress-induced anxiety is relatively limited. Based on "traditional theory+clinical data+animal experimental data", this article proposes a new hypothesis of "multiple setbacks and obstructed intentions" causing anxiety, which is defined as "an anxiety state induced by the inability of an individual to meet their own needs, limited or deprived after multiple attempts, which is due to the inability of their desires to be hindered and powerless." This hypothesis is more in line with the typical manifestations of despair, lack of pleasure, and social withdrawal in clinical patients, and is supported by the traditional theory and experimental data of "hunger but unable to eat, food but unable to obtain, and gain but not full." Based on this, the modeling paradigm established is easy to operate, has good repeatability, and low cost, and can be used to establish anxiety models for rats and mice. To provide theoretical and model basis for the development and pharmacological evaluation of anti anxiety drugs.