子宫内膜异位症啮齿类动物模型的研究进展
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1.江南大学无锡医学院;2.南京医科大学附属无锡妇幼保健院;3.江南大学附属妇产医院

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无锡市卫生健康委中青年拔尖人才资助计划 (HB2023080)。


Research Progress of Rodent Animal Models for Endometriosis
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Affiliation:

1.Wuxi School of Medicine, Jiangnan University;2.Wuxi Maternal and Child Health Hospital, Nanjing Medical University;3.Department of Obstetrics and Gynecology, Wuxi Maternity and Child Health Care Hospital;4.yanghezhangbing@163.com

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Funded by Top Talent Support Program for Young and Middle-aged People of Wuxi Health Committee(HB2023080)

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    摘要:

    子宫内膜异位症(endometriosis,EMs)好发于育龄期女性,影响患者身心健康,然而临床上尚无治愈方法。为深入理解其发病机制并指导临床治疗,适宜动物模型的建立至关重要。目前啮齿类动物因成本低、繁殖周期明确、建模耗时短等优点成为首选。传统的子宫内膜异位症啮齿类模型包括自体移植模型、同种异体移植模型及异种移植模型。研究者还对现有模型进行优化以更好的模拟人体疾病状态或临床症状。本文综述各种啮齿类动物子宫内膜异位症模型和影响造模的因素及评估成功率的指标,探讨未来动物模型的发展方向。

    Abstract:

    Endometriosis(EMs) occurs in women of childbearing age and affects the physical and mental health of patients, yet there is no clinical cure. In order to understand the pathogenesis of EMs and guide clinical treatment, the establishment of suitable animal models is essential. Currently, rodents are the preferred choice due to their low cost, well-defined reproductive cycles, and short modeling time. Traditional rodent models of endometriosis include autologous transplantation models, allogeneic transplantation models, and xenogeneic transplantation models. Researchers have also optimized existing models to better simulate human disease states or clinical symptoms. This review summarizes various rodent models of endometriosis, factors influencing model development, and criteria for assessing success rates, and discusses future directions for animal model development.

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  • 收稿日期:2025-04-01
  • 最后修改日期:2025-08-25
  • 录用日期:2025-09-19
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