脊髓损伤后神经源性膀胱动物模型研究进展
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湖南中医药大学

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]国家自然科学基金面上项目(82274666);湖南中医药大学学科建设揭榜挂帅项目(22JBZ013);湖南省自然科学基金青年项目(2024JJ6340)。


Research progress in animal models of neurogenic bladder following spinal cord injury
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Hunan University of Chinese Medicine

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Funded by General Project of National Natural Science Foundation of China (82274666), Discipline Construction 'Leading the Charge with Open Competition' Project of Hunan University of Chinese Medicine (22JBZ013), Youth Project of Hunan Provincial Natural Science Foundation (2024JJ6340).

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    摘要:

    神经源性膀胱(neurogenic bladder, NB)是最具挑战性的泌尿系统疾病之一,脊髓损伤(spinal cord injury, SCI)是其发病的主要原因之一。动物模型是研究SCI后NB发病机制、治疗策略及筛选新药的重要工具。本文通过回顾与整理国内外近年来 SCI后NB动物模型相关的文献,从动物类型、脊髓损伤节段、造模方法、模型评价指标等几个方面归纳和分析 SCI后NB动物模型的研究进展,以期为基于SCI后NB动物模型开展的实验研究提供参考。

    Abstract:

    Neurogenic bladder (NB) stands as one of the most challenging urinary system disorders, with spinal cord injury (SCI) being a primary etiological factor. Animal models serve as crucial instruments for investigating the pathogenesis, therapeutic strategies, and novel drug screening for NB subsequent to SCI. By reviewing and synthesizing recent literature on NB animal models after SCI from both domestic and international sources, this paper summarizes and analyzes the research advancements in such models, encompassing animal species, SCI segments, modeling techniques, and evaluation indicators. The aim is to offer insights and guidance for experimental research based on animal models of NB following SCI.

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  • 收稿日期:2025-04-18
  • 最后修改日期:2025-07-04
  • 录用日期:2025-09-05
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