Ulcerative colitis (UC), a chronic inflammatory bowel disease, is characterized by a complex and yet unclear etiology. In recent years, traditional Chinese medicine (TCM) has demonstrated notable advantages in the treatment of UC. Correspondingly, integrated animal models combining disease and TCM syndromes have emerged as a crucial platform for bridging traditional and modern medical research. The major construction methods of ulcerative colitis animal models were systematically reviewed, and the modeling strategies and implementation approaches integrating the TCM Damp-Heat syndrome were thoroughly analyzed. Furthermore, it explores the incorporation of advanced omics technologies—such as metabolomics and metagenomics—into multidimensional evaluation systems for TCM syndrome models, aiming to achieve objective and quantitative characterization of traditional syndromes. In addition, we propose a novel composite modeling approach that integrates gene-edited models (e.g., mice with targeted deletions in inflammatory signaling genes) with TCM-based damp-heat modeling techniques, to better recapitulate the pathogenesis of UC and its correlation with individual constitution. This integrated strategy holds promise for improving model construction and evaluation systems, enhancing scientific rigor and translational value, and providing theoretical and experimental support for TCM-based interventions in UC.