To address the shortage of donor organs in clinical allogeneic organ transplantation, researchers have started to explore the feasibility of xenotransplantation. In 2002, the world"s first GTKO (α-1,3-galactosyltransferase knockout) pig was created, and its demonstrated reduction in immune rejection effects proved the significance of gene editing in xenotransplantation. At present, with the continuous improvement of somatic cell cloning technology and gene editing technology, researchers have gradually established the research direction of using gene-edited pigs as donors for xenotransplantation. This review summarizes representative global cases of "pig-to-human" xenotransplantation in recent years, elaborates on the experimental results and types of gene editing for each case; For different types of immune rejection reactions, it analyzes the impacts and mechanisms of different gene editing strategies on xenotransplantation; Furthermore, it summarizes the strategies for selecting and combining edited genes, The concept of "tool pigs" for xenotransplantation is proposed, and the problems existing in related studies are discussed, expecting to provide new ideas for optimizing the gene editing strategies of donor pigs for xenotransplantation.