Objective To study a new method for inbred strain mice genetic monitoring.Method 6 random primers were used to amplify DNA in 6 inbred strains of mice (TA1, TA2, T739, C57BL/6,615 and Scid). Results The amplified band patterns were obviously different in the products of 4 primers(p2,p3,p5 and p6).Conclusion The results indicated that different strains of mice could be easily distinguished by RAPD method.