Structural and functional changes of immune system in natural aging SD rats

doi:10.3969/ j. issn. 1005 -4847.2018.01.015

Home > Archive>Volume 26, Issue 1, 2018 >95-100. DOI:10.3969/ j. issn. 1005 -4847.2018.01.015

Structural and functional changes of immune system in natural aging SD rats
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                        10.3969/ j. issn. 1005 -4847.2018.01.015
                    
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Author:
                        ZHU HuaZHU Hua
Key Laboratory of Human Disease Comparative Medicine, Ministry of Health; Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine; Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medical Center, Peking Union Medical College (PUMC)
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YU PinYU Pin
Key Laboratory of Human Disease Comparative Medicine, Ministry of Health; Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine; Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medical Center, Peking Union Medical College (PUMC)
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XU YanfengXU Yanfeng
Key Laboratory of Human Disease Comparative Medicine, Ministry of Health; Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine; Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medical Center, Peking Union Medical College (PUMC)
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LI YanhongLI Yanhong
Key Laboratory of Human Disease Comparative Medicine, Ministry of Health; Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine; Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medical Center, Peking Union Medical College (PUMC)
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HUANG LanHUANG Lan
Key Laboratory of Human Disease Comparative Medicine, Ministry of Health; Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine; Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medical Center, Peking Union Medical College (PUMC)
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HAN YunlinHAN Yunlin
Key Laboratory of Human Disease Comparative Medicine, Ministry of Health; Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine; Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medical Center, Peking Union Medical College (PUMC)
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QIN chuanQIN chuan
Key Laboratory of Human Disease Comparative Medicine, Ministry of Health; Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine; Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medical Center, Peking Union Medical College (PUMC)
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Affiliation:(Key Laboratory of Human Disease Comparative Medicine, Ministry of Health; Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine; Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medical Center, Peking Union Medical College (PUMC))
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Fund Project:CAMS Innovation Fund for Medical Science(No. 2017-12M-2-005)

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Abstract:

Objective To investigate the structural and functional changes of immune system in aging Sprague-Dawley rats. Methods Sixty SPF 4 -6-week old SD rats (male∶ female =1∶ 1) were used in this study. Ten of them were randomly taken and euthanized every 6 months. The dynamic changes of T cell proliferation, expression of cytokines, serum levels of SOD and MDA and histopathology were examined. Results Obvious histological changes of thymus and spleen were observed in the aging rats. Compared with the young SD rats, in the aging rats, the lymphocyte transformation ability was decreased ( P <0.05, P <0.01), number of splenic cells was declined ( P <0.05, P <0.01), NK ( P <0.05, P <0.01) and T cell subset was reduced ( P <0.05, P <0.01), and the production of IL-2 was decreased as well ( P <0.05, P <0.01). The serum level of SOD in old rats was lower, MDA was increased, with significant differences ( P <0.05, P <0.01). The immunohistochemical staining showed that more extensive staining was found in the nuclei of thymocytes from the aging rats, while the 8?OHdG formation in thymic tissues was mostly located in the thymic medulla. Conclusions Aging process is accompanied by immune impairment, oxidative stress can also impair the immune response in aging rats. Our findings indicate that structural and functional alterations of immune system in aging rats may be closely related with oxidative damages.

Key words:SD rat; aging; spleen; thymus; lymphocytes

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Received:April 12,2017
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Online: March 06,2018
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