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Home > Archive>Volume 26, Issue 3, 2018 >331-334. DOI:10.3969/j. issn. 1005 -4847. 2018. 03. 010
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Immunogenicity and safety of Sabin IPV vaccine in Banna mini pigs
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Affiliation:

(Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China)

Fund Project:

National International Science and Technology Cooperation Program of China (No. 2014DFA32870), Xiehe Innovation Team Program (No. 2016?I2M - 3 - 026), Yunnan International Science and Technology Cooperation Program (No. 2017IB008), Yunnan Innovation Team Program (No. 2015HC027)

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    Abstract:

    Objective To evaluate the immunogenicity and safety of inactivated poliovirus vaccine derived from Sabin strain (sIPV) in Banna mini pigs, and to provide experimental evidence for the new animal model. Methods sIPV vaccines which are listed at Institute of Medical Biology at Chinese Academy of Medical Sciences were used in this study. The groups of intramuscular sIPV and the wild strain IPV injections (IPV derived from wild strain, wIPV) were designed, and the saline group was used as a negative control group. The Banna mini pigs in various groups were immunized at 0, 1 and 2 months. Blood samples were collected before immunization and on days 30 after each immunization. Levels of neutralizing antibodies were tested for evaluating immunogenicity. The safety was evaluated by observation of the status and weight of mini pigs. Results After the three dose immunization schedules in the Banna mini pigs, the seroconversion rates of type I, II and III sIPV experimental groups and wIPV group were all up to 100%. The neutralizing antibody levels in all the three types were much higher than the protective titer 1: 8. The weight of mini pigs increased after vaccination. Conclusions The sIPV vaccine has good immunogenicity and safety in Banna mini pigs. Banna mini pigs could be a new animal model for evaluation of sIPV vaccine.

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History
  • Received:February 28,2018
  • Online: July 20,2018
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