Research progress of animal models of renal fibrosis and their characteristics

doi:10.3969/j. issn. 1005 -4847. 2018. 03. 020

Home > Archive>Volume 26, Issue 3, 2018 >398-403. DOI:10.3969/j. issn. 1005 -4847. 2018. 03. 020

Research progress of animal models of renal fibrosis and their characteristics
DOI:
                        10.3969/j. issn. 1005 -4847. 2018. 03. 020
                    
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Author:
                        MA Yuanyuan1MA Yuanyuan
Institute of Liver Diseases, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
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LIU ChenghaiLIU Chenghai
1. Institute of Liver Diseases, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. 2. Shanghai Clinical Key Laboratory of Traditional Chinese Medicine, Shanghai 201203
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TAO Yanyan1TAO Yanyan
Institute of Liver Diseases, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
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Affiliation:(1. Institute of Liver Diseases, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. 2. Shanghai Clinical Key Laboratory of Traditional Chinese Medicine, Shanghai 201203)
Clc Number:
Fund Project:National Science and Technology on New Drug Creation and Development (No. 2018ZX09201001 -001 -006)

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Abstract:

Renal fibrosis is a common pathological pathway of chronic kidney diseases that leads to end?stage renal failure. The pathological changes include glomerulosclerosis and renal interstitial fibrosis. Ideal animal models for the study of pathologic mechanisms and drug development of chronic kidney disease are of great significance. At present, the method of establishment of animal models include drug or toxin induction, surgical models and gene knockout, etc. Different animal models have various characteristics of renal function and pathology, but can not completely simulate human chronic kidney disease, suggesting the complexity of chronic kidney diseases. So the preparation and research of the animal models is important for understanding the pathological mechanisms, prevention and treatment of renal fibrosis.

Key words:renal fibrosis; renal interstitial fibrosis; glomerulosclerosis; animal mode

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Received:December 25,2017
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Online: July 20,2018
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