A review of animal models of post-traumatic stress disorder

doi:10.3969/j. issn. 1005 -4847. 2018. 03. 021

Home > Archive>Volume 26, Issue 3, 2018 >404-409. DOI:10.3969/j. issn. 1005 -4847. 2018. 03. 021

A review of animal models of post-traumatic stress disorder
DOI:
                        10.3969/j. issn. 1005 -4847. 2018. 03. 021
                    
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Author:
                        WANG ChangWANG Chang
Department of Anatomy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
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SHAO ShuijinSHAO Shuijin
Department of Anatomy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
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LIU YupuLIU Yupu
Department of Anatomy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
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ZHU JingZHU Jing
Department of Anatomy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
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Affiliation:(Department of Anatomy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China)
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Fund Project:National Natural Science Foundation of China (No. 81704158), Shanghai Sailing Program (No. 17YF1419600), China Postdoctoral Science Foundation (No. 2017M611610), Budgetary Research Projects of Shanghai University of Traditional Chinese Medicine (No. 2016YSN03)

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Abstract:

Post?traumatic stress disorder (PTSD) is a serious psychiatric disorder when someone suffered from a major trauma, next followed by sleep disorder, emotional and cognitive disorder and other symptoms. Over the past few decades, many stress rodents models have been developed for searching the potential pathophysiological pathways of PTSD. All models showed PTSD?like symptoms, but none of them could manifestate all the symptoms and biological changes of PTSD completely. Thus, this article makes a brief summary about the PTSD models commonly used in recent years.

Key words:post?traumatic stress disorder; hypothalamic pituitary adrenal axis; stress; animal?models

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Received:January 12,2018
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Online: July 20,2018
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