Research progress of preparation technology and retrofit strategy of antibodies from mouse to whole human monoclonal antibodies

doi:10.3969/j. issn. 1005 - 4847. 2018. 04. 020

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Research progress of preparation technology and retrofit strategy of antibodies from mouse to whole human monoclonal antibodies
DOI:
                        10.3969/j. issn. 1005 - 4847. 2018. 04. 020
                    
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Author:
                        SHI LeiSHI Lei
Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China
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LIN JiepingLIN Jieping
Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China
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LIAO ShuzhenLIAO Shuzhen
Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China
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ZHAO ChunfeiZHAO Chunfei
Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China
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LIU HuafengLIU Huafeng
Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China
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PAN QingjunPAN Qingjun
Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China
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Affiliation:(Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China)
Clc Number:Q95-33
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Abstract:

Monoclonal antibodies (mAbs) have become one of the fastest?growing areas in the bio?pharmaceutical industry because of their unique advantages such as high specificity, high potency, and low drug resistance, and they have been successfully used in the treatment of various cancers, autoimmune diseases and other diseases. From the initial development of murine monoclonal antibodies to the current whole human monoclonal antibodies, new preparation techniques, such as single cell sorting and sequencing techniques, have been emerging. Meanwhile, it will help to further improve its stability and affinity by changing the glycosylation level of whole human monoclonal antibody and optimizing the affinity maturation technology of monoclonal antibodies. At present, the efficacy and safety of whole human monoclonal antibodies are still concerned by the industry, and they also face many challenges, such as how to balance them while reducing their immunogenicity, and further improve their affinity, are still promising new technologies or strategies.

Key words:murine; whole human; monoclonal antibody; glycosylation; single cell sorting technology

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Received:May 07,2018
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Online: September 12,2018
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