Research progress of the application of iodoacetamide in animal models of digestive diseases

doi:10.3969/j. issn. 1005 - 4847. 2018. 04. 021

Home > Archive>Volume 26, Issue 4, 2018 >533-539. DOI:10.3969/j. issn. 1005 - 4847. 2018. 04. 021

Research progress of the application of iodoacetamide in animal models of digestive diseases
DOI:
                        10.3969/j. issn. 1005 - 4847. 2018. 04. 021
                    
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Author:
                        LI Jianfeng1LI Jianfeng
Guangxi University of Traditional Chinese Medicine, Nanning 530000, China.
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XIE Sheng2XIE Sheng
First AffilIAted Hospital of Guangxi University of Traditional Chinese Medicine, Nanning 530000
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CHEN Guangwen2CHEN Guangwen
First AffilIAted Hospital of Guangxi University of Traditional Chinese Medicine, Nanning 530000
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LIU Lijian2LIU Lijian
First AffilIAted Hospital of Guangxi University of Traditional Chinese Medicine, Nanning 530000
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Huang Xiaoyan2Huang Xiaoyan
First AffilIAted Hospital of Guangxi University of Traditional Chinese Medicine, Nanning 530000
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YANG Chengning2YANG Chengning
First AffilIAted Hospital of Guangxi University of Traditional Chinese Medicine, Nanning 530000
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LI Juan1LI Juan
Guangxi University of Traditional Chinese Medicine, Nanning 530000, China.
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XIE Jieru2XIE Jieru
First AffilIAted Hospital of Guangxi University of Traditional Chinese Medicine, Nanning 530000
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DAI Wenjie1DAI Wenjie
Guangxi University of Traditional Chinese Medicine, Nanning 530000, China.
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CHEN Mingbing1CHEN Mingbing
Guangxi University of Traditional Chinese Medicine, Nanning 530000, China.
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Affiliation:(1. Guangxi University of Traditional Chinese Medicine, Nanning 530000, China. 2. First AffilIAted Hospital of Guangxi University of Traditional Chinese Medicine, Nanning 530000)
Clc Number:Q95-33
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Abstract:

Iodoacetomide is the alkylation reagent of cysteine and histidine in proteomics, it can inhibit protease vigor and even disappear without protein degeneration, induce cell hypoxia, mucosal injury, anxiety and depression, can basically simulate digestive system diseases such as chronic gastritis, functional dyspepsia, ulcerative colitis pathophysiological mechanism. So it is widely used in the establishment and research of the animal models of chronic gastritis, functional dyspepsia and ulcerative colitis. In this paper, the mechanism and modeling method of the animal models of digestive system diseases are summarized as follows.

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Received:February 06,2018
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Online: September 12,2018
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