Research progress of ferret models of influenza A virus infection

doi:10. 3969 / j.issn.1005-4847. 2019. 02. 020

Home > Archive>Volume 27, Issue 2, 2019 >254-260. DOI:10. 3969 / j.issn.1005-4847. 2019. 02. 020

Research progress of ferret models of influenza A virus infection
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                        10. 3969 / j.issn.1005-4847. 2019. 02. 020
                    
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                        MA ShujieMA Shujie
State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences, Harbin 150069, China
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ZHANG BoZHANG Bo
State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences, Harbin 150069, China
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KONG YufeiKONG Yufei
State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences, Harbin 150069, China
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GUAN YuntaoGUAN Yuntao
State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences, Harbin 150069, China
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Affiliation:(State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences, Harbin 150069, China)
Clc Number:Q95-33
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Abstract:

Influenza A viruses (IAVs) infect humans and animals, and pose continuous threats to public health.Animal models have pivotal roles in IAV research, and different animal models have different advantages and limitations.We focused on the advantages and disadvantages of the use of ferrets, and compared them with those of mice, guinea pigs,and non-human primate models. We highlighted the important role of ferrets in IAV research. This paper briefly reviews theresearch progress in use of ferret models in the studies of pathogenesis, transmission and evaluation of IAVs. As such, it provides references for the basic and applied research of IAVs.

Key words:influenza A virus; ferret; animal model; pathogenesis; transmission; vaccine development

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Received:September 28,2018
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Online: May 05,2019
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