Research progress in establishment and application of mouse models of leukemia

doi:10. 3969 / j.issn.1005-4847. 2019. 02. 022

Home > Archive>Volume 27, Issue 2, 2019 >266-270. DOI:10. 3969 / j.issn.1005-4847. 2019. 02. 022

Research progress in establishment and application of mouse models of leukemia
DOI:
                        10. 3969 / j.issn.1005-4847. 2019. 02. 022
                    
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Author:
                        MA ChangMA Chang
1.Guangdong Institute of Biological Resources Application, Guangdong Provincial Key Laboratory ofAnimal Protection and Resource Utilization, Guangdong Provincial Public Laboratory for WildlifeConservation and Utilization, Guangzhou 510260, China. 2. School of Pharmacy, Henan University,Kaifeng 475000. 3. Guangdong Lewwin Medicine Research Institute Co., Ltd., Guangzhou 510990
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GUO JianminGUO Jianmin
1.Guangdong Institute of Biological Resources Application, Guangdong Provincial Key Laboratory ofAnimal Protection and Resource Utilization, Guangdong Provincial Public Laboratory for WildlifeConservation and Utilization, Guangzhou 510260, China.2. Guangdong Lewwin Medicine Research Institute Co., Ltd., Guangzhou 510990
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XIE Songqiang2XIE Songqiang
School of Pharmacy, Henan University,Kaifeng 475000.
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YANG WeiYANG Wei
1.Guangdong Institute of Biological Resources Application, Guangdong Provincial Key Laboratory ofAnimal Protection and Resource Utilization, Guangdong Provincial Public Laboratory for WildlifeConservation and Utilization, Guangzhou 510260, China.2. Guangdong Lewwin Medicine Research Institute Co., Ltd., Guangzhou 510990
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Affiliation:(1.Guangdong Institute of Biological Resources Application, Guangdong Provincial Key Laboratory ofAnimal Protection and Resource Utilization, Guangdong Provincial Public Laboratory for WildlifeConservation and Utilization, Guangzhou 510260, China. 2. School of Pharmacy, Henan University,Kaifeng 475000. 3. Guangdong Lewwin Medicine Research Institute Co., Ltd., Guangzhou 510990)
Clc Number:Q95-33
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Abstract:

Leukemia is often referred to as a “blood cancer”. The basic characteristic of the disease is thatleukemic cells become malignant and cause unrestricted proliferation in the bone marrow and other hematopoietic tissues.Then, these cells infiltrate all tissues and organs of the body causing various symptoms, and make patients prone to seriousinfections and life-threatening complications such as sepsis, hemorrhage, intestinal failure or hyperuricemia. Therefore,research on the treatment of leukemia using laboratory animal models is of great significance. For the study of leukemia,mice are similar to humans in terms of biology, genetics, and hematopoietic systems, and are, therefore, ideal models forleukemia research. This article reviews the mouse models of leukemia used commonly in studies both in China and abroad in the past 5 years.

Key words:acute leukemia; mouse; model

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Received:July 15,2018
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Online: May 05,2019
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