Current status of research on animal models of intervertebral disc degeneration

doi:10. 3969 / j.issn.1005-4847. 2019. 03. 016

Home > Archive>Volume 27, Issue 3, 2019 >374-379. DOI:10. 3969 / j.issn.1005-4847. 2019. 03. 016

Current status of research on animal models of intervertebral disc degeneration
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                        10. 3969 / j.issn.1005-4847. 2019. 03. 016
                    
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Author:
                        HAI Bao1HAI Bao
Department of Orthopedics, Peking University Third Hospital, Beijing 100191, China.
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ZHU Bin2ZHU Bin
the Center for Pain Medicine, Peking University Third Hospital, Beijing 100191
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LIU XiaoguangLIU Xiaoguang
1. Department of Orthopedics, Peking University Third Hospital, Beijing 100191, China.2. the Center for Pain Medicine, Peking University Third Hospital, Beijing 100191
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Affiliation:(1. Department of Orthopedics, Peking University Third Hospital, Beijing 100191, China.2. the Center for Pain Medicine, Peking University Third Hospital, Beijing 100191)
Clc Number:Q95-33
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Abstract:

Degeneration of intervertebral discs is a major cause of lower back pain that seriously affects quality oflife and productivity. Although the specific pathogenesis is still unclear, recent research of related animal models has madegreat progress. The modeling method include structural damage, stress changes, and gene knockout. In this review, wefocus on the advantages and disadvantages of these Methods and their applications to establish a theoretical foundation for subsequent research.

Key words:intervertebral disc degeneration; nucleus pulposus; annulus fibrosus; animal model; gene knockout

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Received:January 11,2019
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Online: July 09,2019
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