Advances in research of animal models of autism spectrum disorders

doi:10. 3969 / j.issn.1005-4847. 2019. 03. 017

Home > Archive>Volume 27, Issue 3, 2019 >380-386. DOI:10. 3969 / j.issn.1005-4847. 2019. 03. 017

Advances in research of animal models of autism spectrum disorders
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                        10. 3969 / j.issn.1005-4847. 2019. 03. 017
                    
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                        ZHOU RongyiZHOU Rongyi
Department of Pediatrics, the First Affiliated Hospital of Henan University of Chinese Medicine, Children’s Encephalopathy Clinic and Rehabilitation Center of Henan Provincial Hospital of Integrative Medicine,Zhengzhou 450000, China
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DANG WeiliDANG Weili
Department of Pediatrics, the First Affiliated Hospital of Henan University of Chinese Medicine, Children’s Encephalopathy Clinic and Rehabilitation Center of Henan Provincial Hospital of Integrative Medicine,Zhengzhou 450000, China
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ZHOU ZhengZHOU Zheng
Department of Pediatrics, the First Affiliated Hospital of Henan University of Chinese Medicine, Children’s Encephalopathy Clinic and Rehabilitation Center of Henan Provincial Hospital of Integrative Medicine,Zhengzhou 450000, China
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LI HuaweiLI Huawei
Department of Pediatrics, the First Affiliated Hospital of Henan University of Chinese Medicine, Children’s Encephalopathy Clinic and Rehabilitation Center of Henan Provincial Hospital of Integrative Medicine,Zhengzhou 450000, China
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ZHANG XiZHANG Xi
Department of Pediatrics, the First Affiliated Hospital of Henan University of Chinese Medicine, Children’s Encephalopathy Clinic and Rehabilitation Center of Henan Provincial Hospital of Integrative Medicine,Zhengzhou 450000, China
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Affiliation:(Department of Pediatrics, the First Affiliated Hospital of Henan University of Chinese Medicine, Children’s Encephalopathy Clinic and Rehabilitation Center of Henan Provincial Hospital of Integrative Medicine,Zhengzhou 450000, China)
Clc Number:Q95-33
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Abstract:

The global incidence of autism spectrum disorders (ASDs) is increasing. However, the etiology andpathogenesis of ASDs are not known, and animal models are used to disclose them. Understanding of ASDs and their studyusing animal models are relatively new in China. The internationally commonly used animal models of ASD can be dividedbroadly into three categories: genetic animal models, idiomatic animal models, and animal models developed byenvironmental interventions. Among them, the genetic animal model has a high profile but a small scope of application. TheBTBR mouse model (which is an idiomatic animal model) and the animal models developed by environmental interventionsusing valproic acid can present typical clinical symptoms and some pathologic features of ASDs better than those elicited byother models. These two models should be selected before research is commenced. Nevertheless, research into ASDs lacks an “ideal” animal model that meets all the “three types of validity”: structural, surface, and predictive validities.

Key words:autism spectrum disorders; animal model; BTBR model; valproic acid

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Received:November 20,2018
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Online: July 09,2019
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