Spinal cord injury is currently a major focus of research, and the study of spinal cord ischemicreperfusion injury (SCII) has been a major challenge worldwide. Many animal models are currently used to study SCII, but there is still a lack of the most simple, effective and most similar model to human SCII. An animal model of SCII plays avital role in the study of etiology and pathological mechaism of SCII related diseases, as well as in the guidance of clinical medication and the research and development of new drugs. This paper reviews the animal species, methods and applications used in SCII modeling in the relevant literature and describes the establishment of a simple, effective and highly similar model to human SCII.