Perimenopausal syndrome (PMS) is a series of symptoms caused by the decrease of steroid hormone levels, such as estrogen and progesterone, which seriously affect the physical and mental health and quality of life of women. To explore the etiology of the disease, it is important to select the right animal model. The ovariectomy animal model is often used in the study of PMS symptoms, such as osteoporosis, memory and cognitive impairment, anxiety, depression, and obesity. In this paper, research progress of the ovariectomy animal model applied to PMS is reviewed by searching the relevant literature of the ovariectomy animal model in PubMed and CNKI database for PMS.