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Home > Archive>Volume 28, Issue 3, 2020 >390-396. DOI:10. 3969 / j.issn.1005-4847. 2020. 03. 015
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Research progress regarding the application of zebrafish in toxicology
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1.Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China. 2. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028

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    Abstract:

    Drug toxicity has, in significant measure, affected the discovery and application of new pharmaceutical drugs. Zebrafish have been increasingly used as a biological model in drug toxicology research. Here, we reviewed the application of the zebrafish model in drug toxicity research in a number of fields ( including cardiotoxicity, hepatotoxicity, nephrotoxicity, neurotoxicity, genetic and intergenerational toxicity, and teratogenic toxicity). The relative advantages and disadvantages were summarized, thus providing a basis for further application of the zebrafish model in drug toxicity research.

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  • Received:October 29,2019
  • Online: July 03,2020
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