Multiple sclerosis is a chronic inflammatory demyelinating disease of the central nervous system, and a serious disease in the clinical neurological setting. The basic pathological features of MS include inflammatory infiltration, primary demyelination and glial cell activation. Appropriate animal models are necessary for the study of pathogenesis and pathological processes, and for the screening and evaluation of therapeutic drugs. In this review, we will introduce the pathological features and pathogenesis of animal models, as well as the specific MS problems that different models can be applied to.