Objective To illustrates the effect of resveratrol on motor dysfunction and peripheral immunity in α-synuclein A53T mice. Methods Eight-month-old A53T α-syn transgenic mice were randomly divided into four groups:model group (PD), model treatment group (PD + RES), control group (WT) and control treatment group (WT + RES).The treatment groups were given Resveratrol (RES)by gavage every 3 days for 11 months, while the control and modelgroups were given an equal volume of normal saline. The motoric function of the animals was analyzed with a forelimb gripstrength test, Rotarod test, and Pole climbing test. The proportion of T lymphocyte subsets in different groups of mice wasdetected by flow cytometry. IL-6, TNF-α, IL-18 and TGF-β in each group were detected by an ELISA kit. Results themotor function scores in the PD group were worse than those in the WT group. Compared with the PD group, the motorfunction score of the PD + RES group was significantly improved. The flow cytometry result showed that compared with theWT group, the T lymphocyte ratio, CD4⁺ T cell ratio, and CD4⁺ / CD8⁺ ratio were less in the PD group, while the CD8⁺ Tcell ratio was not significantly different. After RES treatment, T lymphocytes, CD4⁺ cells, and the CD4⁺ / CD8⁺ ratio weresignificantly greater in the PD + RES group than the PD group. The ELISA result showed that compared with the WTgroup, the IL-6 and IL-18 levels in the PD group were greater, the TGF-β level were less, and the TNF-α level showed nosignificant statistical difference. After RES treatment, compared with the PD group, the IL-6 and IL-18 levels in the PD +RES group were significantly less, while the TGF-β level was greater; however, the result showed no statistical difference. Conclusions Resveratrol can reduce motor disorders, regulate peripheral immune function, and effectively reduceneuroinflammation.