Malignant pancreatic cancers show a high degree of malignancy, a poor prognosis, and high rates of morbidity and mortality. Mouse models of pancreatic cancer demonstrate certain characteristics of human pancreatic tumors and are useful for studying cancer prevention and treatment. Mouse models are divided into induced, transplanted, and genetically engineered models, each of which shows specific characteristics of human pancreatic cancer. Various mouse models are reviewed in the present report.