Construction and evaluation of a model of atherosclerotic blood-stasis and toxic syndrome based on a combination of disease and syndrome

doi:10. 3969 / j.issn.1005-4847. 2023. 01. 012

Home > Archive>Volume 31, Issue 1, 2023 >98-105. DOI:10. 3969 / j.issn.1005-4847. 2023. 01. 012

Construction and evaluation of a model of atherosclerotic blood-stasis and toxic syndrome based on a combination of disease and syndrome
DOI:
                        10. 3969 / j.issn.1005-4847. 2023. 01. 012
                    
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Author:
                        ZHANG Xiaonan2,3,1ZHANG Xiaonan
1. National Clinical Research Center for Chinese Medicine Cardiology, China Academy of Chinese Medical Sciences, Xiyuan Hospital, Beijing 100091, China.
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WU MinWU Min
2. China Academy of Chinese Medical Sciences, Guang’anmen Hospital, Beijing 100053.
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SUN ChangxinSUN Changxin
3. Beijing University of Chinese Medicine, Beijing 100029
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CHEN Jiye2,3,1CHEN Jiye
1. National Clinical Research Center for Chinese Medicine Cardiology, China Academy of Chinese Medical Sciences, Xiyuan Hospital, Beijing 100091, China.
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LI Xiaoya2,3,1LI Xiaoya
1. National Clinical Research Center for Chinese Medicine Cardiology, China Academy of Chinese Medical Sciences, Xiyuan Hospital, Beijing 100091, China.
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LIU Longtao2,3,1LIU Longtao
1. National Clinical Research Center for Chinese Medicine Cardiology, China Academy of Chinese Medical Sciences, Xiyuan Hospital, Beijing 100091, China.
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Affiliation:1. National Clinical Research Center for Chinese Medicine Cardiology, China Academy of Chinese Medical Sciences, Xiyuan Hospital, Beijing 100091, China. 2. China Academy of Chinese Medical Sciences, Guang’anmen Hospital, Beijing 100053. 3. Beijing University of Chinese Medicine, Beijing 100029
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Abstract:

Atherosclerosis (AS) is a common pathological basis of cardiovascular and cerebrovascular diseases. Establishing an animal model of AS with the characteristics of blood-stasis toxin syndrome and a standardized evaluation system is an important part of modern cardiovascular and cerebrovascular disease research. This model and system are of great significance to research and development of traditional Chinese medicine for the prevention and treatment of cardiovascular and cerebrovascular diseases and the evaluation of drug efficacy mechanisms. This review summarizes and generalizes the construction and evaluation of animal models of atherosclerotic blood-stasis and toxic syndrome. The review further analyzes the problems existing with current model construction and evaluation to provide a reference for the establishment of standardized animal models.

Key words:atherosclerosis; blood-stasis and toxin syndrome; animal models; combination of disease and syndrome

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Received:August 15,2022
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Online: October 17,2023
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