Atherosclerosis (AS) is a common pathological basis of cardiovascular and cerebrovascular diseases. Establishing an animal model of AS with the characteristics of blood-stasis toxin syndrome and a standardized evaluation system is an important part of modern cardiovascular and cerebrovascular disease research. This model and system are of great significance to research and development of traditional Chinese medicine for the prevention and treatment of cardiovascular and cerebrovascular diseases and the evaluation of drug efficacy mechanisms. This review summarizes and generalizes the construction and evaluation of animal models of atherosclerotic blood-stasis and toxic syndrome. The review further analyzes the problems existing with current model construction and evaluation to provide a reference for the establishment of standardized animal models.