The modified multi-platform method (MMPM) is developed from single-platform and multi-platform method and is mostly used to prepare sleep deprivation (SD) animal models. Compared with single-platform and early multi-platform method, MMPM expands the range of activities that animals partake in and decreases the stress caused by group separation and social isolation. Thus, MMPM can increase the social stability of SD animals. The advantages of MMPM, high simplicity and applicability and low mortality, contribute to the popularity in preparing the animal model of SD in China and other countries. However, many experimental factors affect the modeling effects of MMPM,resulting in uneven modeling effects in different SD studies. In this article, to improve the stability and reproductivity of the experimental SD and provide a reference for further, the specific application and evaluation method of MMPM in SD animal models are reviewed.