Sj?gren’s syndrome (SS), also known as primary Sj?gren’s syndrome (pSS), is a chronic systemic autoimmune disease that mainly involves the exocrine glands. Patients predominantly suffer from dry mouth and dry eyes, and some patients may develop systemic damage. The etiology and pathogenesis of pSS still remain unclear, and clinical treatments are scarce. Studying pSS using animal models is an effective way to elucidate the etiology and pathogenesis of this human disease; however, the result obtained from different animal models should be carefully evaluated. In this review, three classes of SS-like mice are discussed, with special attention given to the heterozygous variant mouse model to provide a guide to those studying pSS.