Precocious puberty is a common endocrine disease in children. Animal experiments are essential in the study of the pathogenesis and drug treatment of precocious puberty. Therefore, establishing an appropriate animal model is a prerequisite for studying the condition. The pubertal development processes in rats and non-human primates are similar to those in humans, and the indications of gonadal development are clear. Rats and non-human primates are common animal models of precocious puberty. According to different research needs, there are many modeling method of precocious puberty, such as danazol, N-methyl-DL-aspartic acid, estradiol, high-fat feed, low-safety environment, light and melatonin, manganese exposure, environmental endocrine disruptors, brain radiation, and intracerebral drug injection. At present, vaginal opening time, vaginal smear and estrous cycle observations, serum sex hormone level determination, hypothalamic gene-level index detection, sexual organ detection, and others, are the most common indicators used to evaluate precocious puberty during animal experiments.