The incidence and mortality of lung cancer are high. It is very important to establish an appropriate animal model of lung cancer to conduct reductive studies on its pathogenesis, mechanism, and drug effects. Animal models of transplanted lung cancer are widely used because of the various transplantation method and simple operation. This article reviews orthotopic and heterotopic transplantation in animal models of transplanted lung cancer from three aspects, the transplantation host, source of the graft, and method of establishment, to provide ideas to establish and select lung cancer models.