Objective To investigate the effect of combined sodium creatine phosphate and trimetazidine on echocardiography and cardiac serology in rats with alcoholic cardiomyopathy. Methods A rat model of alcoholic cardiomyopathy was established by chronic alcohol gavage. After successful modeling, rats were randomly divided into creatine phosphate (CPS), trimetazidine (TMZ), creatine phosphate + trimetazidine(CPS + TMZ) group, normal saline group (NS), and alcohol (AL) groups. The study was conducted for 8 weeks. Echocardiography was used to measure left ventricular end?diastolic diameter(LVEDd), ventricular septal end?diastolic thickness(IVSDd), left ventricular posterior wall end?diastolic thickness(LVPWDd), and left ventricular ejection fraction(EF). Serum creatine kinase CK?MB, high? sensitivity troponin I (Hs?TnI), lactate dehydrogenase (LDH), and amino?terminal brain natriuretic peptide (Nt?proBNP) were also measured. Results (1) Compared with AL and NS groups, LVEDd was decreased, EF was increased, and CK?MB, Hs?TnI, and LDH were decreased in CPS and TMZ groups. (2) Compared with CPS and TMZ groups, LVEDd was decreased, EF was increased, and CK?MB, Hs?TnI, LDH, and Nt?proBNP were decreased in the CPS + TMZ group. (3)There was no statistical difference in each index between CPS and TMZ groups. Conclusions Both creatine phosphate and trimetazidine have a therapeutic effect on alcoholic cardiomyopathy, and their combined effect is better than that of either alone.