Application of a HIV animal model in drug abuse research

doi:10. 3969 / j.issn.1005-4847. 2023. 05. 012

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Application of a HIV animal model in drug abuse research
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                        10. 3969 / j.issn.1005-4847. 2023. 05. 012
                    
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                        WANG Chan2,3,1WANG Chan
1. Department of Forensic Medicine, School of Forensic Medicine, Kunming Medical University, Kunming 650500, China.
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YANG GenmengYANG Genmeng
1. Department of Forensic Medicine, School of Forensic Medicine, Kunming Medical University, Kunming 650500, China. 3. NHC Key Laboratory of Drug Addiction Medicine, Kunming 650500
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LIU Liu2,3,1LIU Liu
1. Department of Forensic Medicine, School of Forensic Medicine, Kunming Medical University, Kunming 650500, China.
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WANG Haowei2,3,1WANG Haowei
1. Department of Forensic Medicine, School of Forensic Medicine, Kunming Medical University, Kunming 650500, China.
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MIAO Lin2,3,1MIAO Lin
1. Department of Forensic Medicine, School of Forensic Medicine, Kunming Medical University, Kunming 650500, China.
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LI Yi2,3,1LI Yi
1. Department of Forensic Medicine, School of Forensic Medicine, Kunming Medical University, Kunming 650500, China.
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LI JuanLI Juan
2. Department of Pathogen Biology and Immunology, Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500. 3. NHC Key Laboratory of Drug Addiction Medicine, Kunming 650500
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ZENG XiaofengZENG Xiaofeng
1. Department of Forensic Medicine, School of Forensic Medicine, Kunming Medical University, Kunming 650500, China. 3. NHC Key Laboratory of Drug Addiction Medicine, Kunming 650500
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Affiliation:1. Department of Forensic Medicine, School of Forensic Medicine, Kunming Medical University, Kunming 650500, China. 2. Department of Pathogen Biology and Immunology, Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500. 3. NHC Key Laboratory of Drug Addiction Medicine, Kunming 650500
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Abstract:

The comorbidity of drug abuse and human immunodeficiency virus (HIV) infection has attracted much attention. Drug abuse is a promoter of HIV transmission. It also aggravates the viral load in the central nervous system and accelerates the progression of HIV?associated neurocognitive disorders. This article focuses on the commonly used animal models related to HIV infection, such as non?human primates, rodents, and felines, analyzes their limitations and advantages, and summarizes the latest research progress of animal models related to HIV infection in drug abuse.

Key words:human immunodeficiency virus; drug abuse; non⁃human primate model; rodent model associated with HIV infection; FIV/ feline model

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Received:March 01,2023
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Online: September 06,2023
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