Laboratory animals, as substitutes for suffering, have made important contributions to the development of medical life sciences for humans. Although various initiatives and regulations of the welfare and ethics of laboratory animals are continually being proposed and applied worldwide, because the demand and use of laboratory animals have been continuously increasing, the contradictions and controversy of laboratory animal welfare and ethics have become more prominent. Laboratory animal welfare ethics in our country were carried out relatively late. Therefore, the development of these ethics is necessary and urgent. At present, the laws and regulations of our country should be improved by referring to international standards and requirements, and combining them with our culture and current situation. Accelerating promotion of welfare ethics certification and evaluation starting from the laboratory animal industry, improving ethical review and evaluation, realizing the supervision of the whole process gradually, promoting the work responsibilities and status of veterinarians, and strengthening the education and awareness of practitioners will implement practical benefits for the welfare and rights of laboratory animals.