Application of brain organoids in the study of traumatic brain injury
Author:
Affiliation:

1. the First Clinical Medical College,Gansu University of Chinese Medicine, Lanzhou 730000, China. 2. Laboratory Animal Center, Air Force Military Medical University, Xi’an 710032. 3. School of Medicine, Yan’an University, Yan’an 716000

  • Article
  • | |
  • Metrics
  • | | | | |
  • Comments
    Abstract:

    Traumatic brain injury (TBI) is the destruction of normal brain functions and/ or pathological injury of brain tissue caused by external force. Because of the irreversible loss of functional neurons and nerve tissue damage, the central nervous system has difficulty repairing and regenerating after trauma, and the prognosis of TBI patients has serious sequelae. The existing TBI models cannot represent the characteristics of the human brain. Although many preclinical studies of TBI therapy have been successful, few have led to clinical translation. As a self?assembled 3D tissue with a collection of stem cells and organ?specific cell types, brain organoids simulate the structure and function of the natural brain to a certain extent. They effectively resolve the limitations of tissue acquisition in the human central nervous system and the mismatch of biological characteristics between humans and animals in TBI research. Therefore, in this review, we summarize the generation, characteristics, and application of brain organoids as TBI models and focus on the research progress of brain organoids simulated in vitro and chimeric animal models with TBI based on human pluripotent stem cells to provide new ideas for the application of brain organoids in the research and treatment of TBI injuries.

    Reference
    Related
    Cited by
Get Citation
Share
Article Metrics
  • Abstract:736
  • PDF: 688
  • HTML: 0
  • Cited by: 0
History
  • Received:December 28,2022
  • Online: September 06,2023
Article QR Code