Abstract:The mouse hind limb ischemic model is a classic model used to study peripheral arterial disease. Six modeling method have been used to date: arterial ligation, interventional embolization, photochemical embolization, chemical injury, physical injury, and ameroid constrictor. This article reviews the anatomy of the murine hind limb artery and unifies the names of the major branches of the hind limb. We also introduce the modeling and evaluation method used in the mouse hind limb ischemia model, and compare the differences, advantages, and disadvantages of the existing method. Notably, mouse strain, sex, age, and method of anesthesia may affect the model. This report thus provides a comprehensive review of the modeling method of the mouse hind limb ischemia model and provides a reference for researchers to help them to select appropriate models according to their research direction.