Drug-induced liver injury is one of the most common adverse clinical drug reactions, potentially resulting in acute liver failure or even death. Clinically however, there is still a lack of specific diagnostic and treatment method for this kind of injury. The construction of corresponding animal models is an important process to support in-depth mechanistic research and screening of effective diagnostic and treatment method. Numerous animal models of drug-induced liver injury have been established and are widely used, including liver injury models induced by non-steroidal antiinflammatory, anti-bacterial, anti-epileptic, and anti-thyroid drugs, with mice and rats being the most commonly used animals. In this report, we review the preparation method, modeling standards, and characteristics of these types of animal models in combination with recent literature reports, to provide references for the future construction of related models.