Application and development of germ-free animals for gut microbiome research

doi:10. 3969 / j.issn.1005-4847. 2023. 07. 014

Home > Archive>Volume 31, Issue 7, 2023 >946-954. DOI:10. 3969 / j.issn.1005-4847. 2023. 07. 014

Application and development of germ-free animals for gut microbiome research
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                        10. 3969 / j.issn.1005-4847. 2023. 07. 014
                    
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                        HU YaqianHU Yaqian
1. School of Basic Medicine, Yunnan University of Chinese Medicine/ Yunnan Key Laboratory of Molecular Biology of Traditional Chinese Medicine, Kunming 650500, China. 2. Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou 510632. 3. School of Basic Medicine and Public Health, Jinan University/ Guangzhou Key Laboratory for Germ-free Animals and Microbiota Application, Guangzhou 510632
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WANG ShanshanWANG Shanshan
1. School of Basic Medicine, Yunnan University of Chinese Medicine/ Yunnan Key Laboratory of Molecular Biology of Traditional Chinese Medicine, Kunming 650500, China. 2. Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou 510632. 3. School of Basic Medicine and Public Health, Jinan University/ Guangzhou Key Laboratory for Germ-free Animals and Microbiota Application, Guangzhou 510632
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ZHANG Tong2,3,1ZHANG Tong
1. School of Basic Medicine, Yunnan University of Chinese Medicine/ Yunnan Key Laboratory of Molecular Biology of Traditional Chinese Medicine, Kunming 650500, China.
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YUAN Jiali2,3,1YUAN Jiali
1. School of Basic Medicine, Yunnan University of Chinese Medicine/ Yunnan Key Laboratory of Molecular Biology of Traditional Chinese Medicine, Kunming 650500, China.
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NIU HaitaoNIU Haitao
1. School of Basic Medicine, Yunnan University of Chinese Medicine/ Yunnan Key Laboratory of Molecular Biology of Traditional Chinese Medicine, Kunming 650500, China. 2. Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou 510632. 3. School of Basic Medicine and Public Health, Jinan University/ Guangzhou Key Laboratory for Germ-free Animals and Microbiota Application, Guangzhou 510632
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Affiliation:1. School of Basic Medicine, Yunnan University of Chinese Medicine/ Yunnan Key Laboratory of Molecular Biology of Traditional Chinese Medicine, Kunming 650500, China. 2. Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou 510632. 3. School of Basic Medicine and Public Health, Jinan University/ Guangzhou Key Laboratory for Germ-free Animals and Microbiota Application, Guangzhou 510632
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Abstract:

In recent years, with the introduction of the concept of metagenomics, human metagenomics has also become a new approach to reveal the development and health of humankind. As the largest microflora in the human body, the gut microbiome has been found to play an important role in the normal physiological functions of the human body and the occurrence and development of diseases. The variety and quantity of gut microbiome are abundant. In studies of the gut microbiome, the application of germ-free animals makes the experiments more accurate and convenient. It is an ideal basic animal model, which is of great significance to the research of microecology. This review summarizes the current understanding of germ-free animals, the application of germ-free animals in experimental research, and the prospects of germ-free animal models to review the application and development of germ-free animals in research of the gut microbiome.

Key words:germ-free animals; gut microbiota; animal models

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Received:November 07,2022
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Online: October 17,2023
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