Objective To investigate the effects of three Tiao-Bu Fei-Shen therapies on interleukin (IL)-6, IL-33, and interferon (IFN)-γ in the lung and intestines of rats with stable chronic obstructive pulmonary disease (COPD). Methods Sixty Sprague-Dawley rats were divided randomly into blank (Control), COPD model (Model), Bufei Jianpi (BJ), Bufei Yishen (BY), Yiqi Zishen ( ZS), and aminophylline ( Am) groups. A stable COPD rat model was established by cigarette-smoke exposure combined with lipopolysaccharide nasal drip in the first 8 weeks. The model rats were given normal saline, Bufei Jianpi Formula, Bufei Yishen Formula, Yiqi Zishen Formula, or aminophylline by gavage for 4 weeks. Morphological changes in the lung and colon were observed by light microscopy, and IL-6, IL-33, and IFN-γ protein levels in lung and colon tissues were localized and analyzed semi-quantitatively by immunohistochemistry. Results Rats in the model group had more inflammatory cells and inflammatory exudates around the bronchi and alveolar spaces compared with control rats, and also had more inflammatory cell infiltration in the colon mucosa and significantly increased levels of IL-6, IL-33, and IFN-γ in the lung and colon tissues (P< 0. 05, P< 0. 01). Bronchial and alveolar inflammatory cell infiltration and colonic mucosal inflammatory cells were decreased in all treatment groups compared with the model group. IL-33 and IFN-γ in the lung and colon and IL-6 in the colon were significantly decreased (P< 0. 05, P<0. 01), and IL-6 in the lung was significantly reduced in the BY, ZS, and Am groups (P< 0. 01). There were positive correlations between lung IL-6 and colon IL-6, lung IL-33 and colon IL-33, and lung IFN-γ and colon IFN-γ levels. Conclusions The three tested Tiao-Bu Fei-Shen therapies can reduce intestinal dysfunction in COPD rats. The mechanism may be related to inhibition of the release of IL-6, IL-33, and IFN-γ in lung and colon tissues, and reducing the inflammatory reaction between the lung and intestine.