Connective tissue disease?interstitial lung disease is a common clinical rheumatic immune disease. Its etiology and pathogenesis are unknown, which causes a significant family and social burden to patients. Animal models are indispensable for research of CTD?ILD. Successful establishment of an animal model in line with the development of human disease is important to study the disease mechanism and develop therapeutic drugs. Therefore, by summarizing domestic and foreign literature on animal models related to CTD?ILD, this article summarizes the method, characteristics and shortcomings of model establishment to provide reference for researchers in related fields to select appropriate animal models.